Diabetes mellitus (DM)-insulin-dependent (type 1): molecular basis and Cell Therapy
Objectives
Offer alternative therapies for DM1 through:
a) Transplantation of pancreatic islets isolated from human cadaveric pancreas;
b) Encapsulation of pancreatic islets for reversal of diabetes induced animal model;
c) New biolopymers generation for islets encapsulation;
d) Differentiation of stem cells (embryonic and adult) in insulin-producing cells;
e) Genomic, transcriptomics and proteomics analysis aiming the identification of new therapeutic targets.
Human pancreatic islets obtained in NUCEL, stained with dithizone (red) indicating the presence of insulin, with some acini (green).
Projects in development
- Differentiation of stem cells into Insulin Producing Cells (IPCs);
- Pancreatic islets encapsulation;
- Genomics, transcriptomics and proteomics;
- New biopolymers for cell encapsulation;
- Isolation of porcine beta cell lines;
- Transplantation of porcine pancreatic islets.
Sectors of Application
- People health care;
- Development of new materials;
- Product development technology for human health.
Sectors of Application
- Health Care of People
- Development of New Materials
- Product Development Technology Geared for Human Health